Ethylcellulose Controlled Release Coating: Effects of Plasticizers

Ethylcellulose Controlled Release Coating: Effects of Plasticizers

  • ethylcellulose controlled release coating: 40/60 ethyl

    Ethylcellulose Controlled Release Coating: 40/60 Ethyl

    Ethylcellulose Controlled Release Coating: Effects of Plasticizers, Additives, and Solvents Karen A. Coppens, Tina P. Dasbach The Dow Chemical Company, Midland, Michigan 48674, USA Introduction Ethylcellulose (EC) is a water-insoluble polymer, which has been used successfully for coating applications in drug delivery with

  • polymer blends for controlled release coatings - sciencedirect

    Polymer blends for controlled release coatings - ScienceDirect

    The use of polymer blends as coating materials for controlled drug delivery systems can offer major advantages, including: (i) facilitated adjustment of desired drug release patterns, mechanical properties and drug release mechanisms, (ii) improved film formation and storage stability, and (iii) the possibility to develop novel strategies for site specific drug delivery within the gastro ...

  • controlled-release film coatings based on ethylcellulose

    Controlled-Release Film Coatings Based on Ethylcellulose

    Controlled-Release Film Coatings Based on Ethylcellulose. ... Formulation variables such as effect of polymer, plasticizer, pore former, pH adjuster, antitacking agents, and wetting liquids are ...

  • controlled release of ammonium nitrate from ethylcellulose

    Controlled Release of Ammonium Nitrate from Ethylcellulose

    Controlled Release of Ammonium Nitrate from Ethylcellulose Coated Formulations ... importance of the type of plasticizer. J. Controlled Release 2004 ... The effect of coating the fertilizers with ...

  • influence of storage conditions and type of plasticizers on

    Influence of storage conditions and type of plasticizers on

    drug release, stability and the final physicochemical properties of the coated dosage forms (4). Ethylcellulose (5, 6) and acrylates (7) are among the most commonly used polymers in the production of coated controlled-release dosage forms. As these poly-mers are insoluble in water, they have to be applied

  • controlled release of ammonium nitrate from ethylcellulose

    Controlled Release of Ammonium Nitrate from Ethylcellulose

    Different ammonium nitrate controlled-release (CR) systems based on ethylcellulose have been investigated to reduce environmental pollution derived from nitrogen-fertilizer use. Coated ammonium nitrate granules were produced in Wurster-type fluidized-bed equipment using two different amounts of ethylcellulose.

  • role of plasticizer in membrane coated extended release oral

    Role of plasticizer in membrane coated extended release oral

    Hence, it is advisable to utilize more than one approach to select a plasticizer for the controlled release membrane system. 4.3. Processability. It is essential that after incorporation of plasticizer in the coating dispersion, the coating dispersion can be coated on pellets or tablets.

  • ethylcellulose coating: effects of viscosity grade, coating

    Ethylcellulose Coating: Effects of Viscosity Grade, Coating

    Ethylcellulose solutions for controlled-release coating typically contain a plasticizer to increase the polymer flexibility. Combinations of dibutyl sebacate with ethylcellulose as a coating formulation for the con-trolled release of diphenhydramine HCl can be found in the literature.3 Typical plasticizer content ranges from 1 to 3%. A ...

  • ethocel™ ethylcellulose a technical review

    ETHOCEL™ Ethylcellulose A Technical Review

    ETHOCEL™ Ethylcellulose - Technical Bulletin | 02-2016 ETHOCELTM Polymers have a long history in film and bead coating for controlled release applications. ETHOCELTM forms a strong film with good adhesion. These polymers can offer a versatile diffusion barrier whose properties can be modified by film thickness (weight

  • mechanism of release from pellets coated with an

    MECHANISM OF RELEASE FROM PELLETS COATED WITH AN

    ethylcellulose-based pseudolatex widely accepted for use as a sustained release coating for phar- maceuticals. Possible mechanisms for release include solution/diffusion through the continuous polymer phase and/or plasticizer channels, diffusion through aqueous pores and osmotically dri- ven release through aqueous pores.

  • controlled release of ammonium nitrate from ethylcellulose

    Controlled Release of Ammonium Nitrate from Ethylcellulose

    Different ammonium nitrate controlled-release (CR) systems based on ethylcellulose have been investigated to reduce environmental pollution derived from nitrogen-fertilizer use. Coated ammonium nitrate granules were produced in Wurster-type fluidized-bed equipment using two different amounts of ethylcellulose.

  • curing of aqueous polymeric film coatings: importance of the

    Curing of aqueous polymeric film coatings: Importance of the

    Effects of the type of plasticizer on diltiazem HCl release from pellets coated with aqueous ethylcellulose dispersion. The coating level and curing conditions are indicated in the figure. in the case of 1 h curing at 60 °C.

  • evaluation of alternative plasticizers for surelease, an

    Evaluation of Alternative Plasticizers for Surelease, an

    Evaluation of Alternative Plasticizers for Surelease®, an Aqueous Ethylcellulose Dispersion for Modified Release Film-Coating Charles F. Vesey, Thomas Farrell, Ali R. Rajabi-Siahboomi New Product Development, Colorcon, West Point, PA 19486 E.mail: modified_release@colorcon Introduction Ethylcellulose, a water-insoluble polymeric film ...

  • influence of additives on ethylcellulose coatings - 123doc.org

    Influence of additives on ethylcellulose coatings - 123doc.org

    . of films 73 1. Comparison between different polymeric films 73 2. Influence of plasticizers on properties of films 74 3. Influence of storage time on properties of films 75 4. Influence of. plasticizers. In addition, the stability of ethylcellulose

  • excipient update – solvent-less film coatings: new

    EXCIPIENT UPDATE – Solvent-Less Film Coatings: New

    Ethylcellulose is a widely used film-forming polymer used to impart modified-release characteristics or mask poor-tasting ingredients. Ethylcellulose is broadly accepted due to its outstanding safety profile and ease of use in conventional spray-coating equipment.

  • influence of additives on ethylcellulose coatings - core.ac.uk

    INFLUENCE OF ADDITIVES ON ETHYLCELLULOSE COATINGS - core.ac.uk

    Ethylcellulose and acrylates are among the most commonly used polymers in the production of coated controlled-release dosage forms. Several researchers have studied the effects of different types of plasticizers on the mechanical properties of Aquacoat films. Plasticizers, such as dibutyl sebacate, tributyl citrate, acetyl tributyl

  • influence of storage conditions and type of plasticizers on

    Influence of storage conditions and type of plasticizers on

    Changes in film mechanical properties may ultimately influence the drug release, stability and the final physicochemical properties of the coated dosage forms (4). Ethylcellulose (5, 6) and acrylates (7) are among the most commonly used polymers in the production of coated controlled-release dosage forms.

  • the effect of curing on drug release and morphological

    The Effect of Curing on Drug Release and Morphological

    With chlorpheniramine maleate, a drug with low affinity for the ethylcellulose coating, a curing step was necessary at intermediate plasticizer levels to obtain good film formation and a limiting drug release pattern, while the use of higher plasticizer levels eliminated the need for a curing step.

  • mechanism of release from pellets coated with an

    MECHANISM OF RELEASE FROM PELLETS COATED WITH AN

    ethylcellulose-based pseudolatex widely accepted for use as a sustained release coating for phar- maceuticals. Possible mechanisms for release include solution/diffusion through the continuous polymer phase and/or plasticizer channels, diffusion through aqueous pores and osmotically dri- ven release through aqueous pores.

  • preparation of ethylcellulose latex by aqueous dispersions

    Preparation of Ethylcellulose Latex by Aqueous Dispersions

    plasticizer used in polymer blends for the coating of solid dosage forms is of major importance for the resulting film coating properties and, thus, drug release kinetics. The project aims to study the combined effect of plasticizers on the glass transition temperature and evaporation rate and to get

  • ethylcellulose coating: effects of viscosity grade, coating

    Ethylcellulose Coating: Effects of Viscosity Grade, Coating

    Ethylcellulose solutions for controlled-release coating typically contain a plasticizer to increase the polymer flexibility. Combinations of dibutyl sebacate with ethylcellulose as a coating formulation for the con-trolled release of diphenhydramine HCl can be found in the literature.3 Typical plasticizer content ranges from 1 to 3%. A ...

  • influence of additives on ethylcellulose coatings - 123doc.org

    Influence of additives on ethylcellulose coatings - 123doc.org

    . of films 73 1. Comparison between different polymeric films 73 2. Influence of plasticizers on properties of films 74 3. Influence of storage time on properties of films 75 4. Influence of. plasticizers. In addition, the stability of ethylcellulose

  • preparation of ethylcellulose latex by aqueous dispersions

    Preparation of Ethylcellulose Latex by Aqueous Dispersions

    plasticizer used in polymer blends for the coating of solid dosage forms is of major importance for the resulting film coating properties and, thus, drug release kinetics. The project aims to study the combined effect of plasticizers on the glass transition temperature and evaporation rate and to get

  • application of ethylcellulose coating to hydrophilic matrices

    Application of Ethylcellulose Coating to Hydrophilic Matrices

    Application of Ethylcellulose Coating. Matrix tablets of HCTZ were coated with an insoluble barrier membrane (BM) using aqueous ethylcellulose coating, Surelease® (containing medium chain triglyceride as plasticizer) and an HPMC-based Opadry® (HPMC low viscosity grade, 6 cps, triacetin, and talc) as a pore former, at 85:15 and 60:40 w/w ratios.

  • excipient update – solvent-less film coatings: new

    EXCIPIENT UPDATE – Solvent-Less Film Coatings: New

    Ethylcellulose is a widely used film-forming polymer used to impart modified-release characteristics or mask poor-tasting ingredients. Ethylcellulose is broadly accepted due to its outstanding safety profile and ease of use in conventional spray-coating equipment.

  • ethylcellulose applications in multiparticulate systems

    Ethylcellulose Applications in Multiparticulate Systems

    Vesey CF, Farrell T, Rajabi-Siahboomi AR. Evaluation of alternative plasticizers for Surelease®, an aqueous ethylcellulose dispersion for modified release film coating. Miami: Controlled Release Society Annual Meeting and Exposition; 2005. Google Scholar

  • controlled release of ammonium nitrate from ethylcellulose

    Controlled Release of Ammonium Nitrate from Ethylcellulose

    Using an empirical equation, the time taken for 50% of the active ingredient to be released into water and soil (T50) was calculated. From the analysis of the T50 values, we can deduce that the release rate of ammonium nitrate can be controlled, mainly changing the thickness of the coating film and using pl...

  • effects of plasticizer and thermal curing on mesalazine

    Effects of Plasticizer and Thermal Curing on Mesalazine

    Effects of Plasticizer and Thermal Curing on Mesalazine Release from Pellets Coated with Aqueous Ethylcellulose Dispersion for Colon Targeted Delivery FU Chong Dong, ZHANG Yu, XU Hui Nan (Dept. of Pharmaceutics, School of Pharmacy, Shanghai Medical University, Shanghai 200032)

  • plasticizers in film coating of tablets |authorstream

    Plasticizers in Film Coating of Tablets |authorSTREAM

    Effect of plasticizers on release rates of drug . : Effect of plasticizers on release rates of drug . 46 Effect of plasticizer type and coat level on aqueous coating dispersions of ethylcellulose. To optimize the most suitable plasticizer and in its most suitable concentration for ethylcellulose (EC). The two plasticizers selected were DBS and GTC.

  • ethylcellulose microparticles: a review

    ETHYLCELLULOSE MICROPARTICLES: A REVIEW

    Ethylcellulose microparticles: a review 13 EC film mechanical characteristics by selecting appropriate EC molecular weights, EC substitution grades, coating weights, and pore formers. The release of a highly or sparingly soluble drug from a dosage from is considerably reduced when osmolal-ity of the dissolution medium is increased causing a