Evidence of the Carcinogenicity of Diisononyl Phthalate (DINP)

Evidence of the Carcinogenicity of Diisononyl Phthalate (DINP)

  • evidence of the carcinogenicity of diisononyl phthalate (dinp)

    Evidence of the Carcinogenicity of Diisononyl Phthalate (DINP)

    consultation with the CIC, OEHHA selected diisononyl phthalate as a chemical for consideration for listing by the CIC. Upon selection, the public was given the opportunity to submit information relevant to the assessment of the evidence on the carcinogenicity of diisononyl phthalate. OEHHA reviewed and considered those

  • evidence on the carcinogenicity of diisononyl phthalate (dinp)

    Evidence on the Carcinogenicity of Diisononyl Phthalate (DINP)

    Evidence on the Carcinogenicity of Diisononyl Phthalate (DINP) Rajpal S. Tomar, Ph.D. Rose Cendak, M.S. Meeting of the Carcinogen Identification Committee . December 5, 2013 . Cancer Toxicology and Epidemiology Section Reproductive and Cancer Hazard Assessment Branch . Office of Environmental Health Hazard Assessment

  • diisononyl phthalate (dinp) - proposition 65 warnings website

    Diisononyl Phthalate (DINP) - Proposition 65 Warnings Website

    DINP is also used in some non-PVC products, such as some inks and pigments, adhesives, sealants, paints and lacquers. California law prohibits the manufacture, sale, or distribution of toys and child care articles intended for the use of a child under 3 years old if that product can be placed in the child’s mouth and it contains DINP at ...

  • diisononyl phthalate (dinp)

    Diisononyl Phthalate (DINP)

    (Diisononyl Phthalate) DINP . DINP exposure Breathing in DINP present in air and dust Transferring DINP from hands to mouth and swallowing Consuming food containing DINP as a result of processing or packaging. How can I reduce my exposure to DINP? Avoid plastics known as polyvinyl chloride (PVC) or vinyl (with recycle code 3).

  • diisononyl phthalate (dinp) carcinogenicity ... - cpsc.gov

    Diisononyl Phthalate (DINP) Carcinogenicity ... - CPSC.gov

    DIISONONYL PHTHALATE (DINP) Carcinogenicity Hazard Assessment Section II discusses the human and primate data relevant to assessing the carcinogenic potential of DINP. Primate studies and in vitro human and primate tests show no evidence of potential carcinogenicity, even under conditions that unquestionably would in rodents provoke

  • weight of evidence indicates that dinp should not be listed

    Weight of Evidence Indicates That DINP Should Not Be Listed

    The most common types of high phthalates include diisononyl phthalate (DINP), diisodecyl phthalate (DIDP) and dipropylheptyl phthalate (DPHP). High phthalates are commonly used in PVC products such as wire and cable, flooring, wall covering, self-adhesive films, synthetic leather, coated fabrics and roofing and automobile applications.

  • addition of diisononyl phthalate category proposed rule

    Addition of Diisononyl Phthalate Category Proposed Rule

    After a review of the available data, EPA preliminarily determined that there was sufficient evidence for including this category of DINP on the EPCRA Section 313 chemical list, because the DINP category can reasonably be anticipated to cause carcinogenicity and liver, kidney, and developmental toxicity. Additional Resources

  • diisononyl phthalate - wikipedia

    Diisononyl phthalate - Wikipedia

    Diisononyl phthalate (DINP) is a phthalate used as a plasticizer. DINP is typically a mixture of chemical compounds consisting of various isononyl esters of phthalic acid, and is commonly used in a large variety of plastic items.

  • diisononyl phthalate: carcinogenic potency database

    Diisononyl phthalate: Carcinogenic Potency Database

    Diisononyl phthalate Results in the Carcinogenic Potency Database. The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals.

  • material safety data sheet di-isononyl phthalate(dinp)

    Material Safety data sheet Di-Isononyl Phthalate(DINP)

    Di-Isononyl Phthalate(DINP) 4 13.Disposal considerations Product: With respect to local regulations,e.g.dispose of to waste incineration plant. Waste code may not be assigned to this product since it admits of a classification only when the consumer uses it for some purpose.

  • iris toxicological review of diisononyl phthalate (dinp

    IRIS Toxicological Review of Diisononyl Phthalate (Dinp

    Notice: EPA hosted an IRIS public science meeting on October 29-30, 2014, to provide an opportunity for the public to give input and participate in an open discussion regarding preliminary materials that were prepared for the IRIS chemicals, hexavalent chromium (Cr(VI)) and diisononyl phthalate (DINP), prior to the development of the draft assessment.

  • diisononyl phthalate (dinp) - home - nicnas

    Diisononyl phthalate (DINP) - Home - NICNAS

    Diisononyl phthalate (DINP) is a member of the group of esters commonly known as phthalates 1. DINP belongs to the High Molecular Weight (HMW) group with straight carbon side chain of ≥ C7 or ring structure. There are no reports of DINP being manufactured as a raw material in Australia.

  • greenscreen™ assessment for diisononyl phthalate (dinp) (cas

    GreenScreen™ Assessment for Diisononyl phthalate (DINP) (CAS

    DINP was assigned a data gap for carcinogenicity. The carcinogenicity of phthalates is controversial. While the EU RAR considered available cancer data to be of unknown relevance to humans, DINP caused multiple types of cancers in multiple species and the mechanisms are not all fully understood. Therefore, DINP is not classifiable as

  • diisononyl phthalate (dinp) - hero.epa.gov

    Diisononyl Phthalate (DINP) - hero.epa.gov

    Excutive summary: Chronic toxicity/carcinogenicity study of diisononyl phthalate (DINP) in the rat with cover letter dated 042386 Author: Exxon Chemical (1986) (EPA/OTS Doc #868600054).

  • (pdf) toxicity review of diisononyl phthalate (dinp). 2010

    (PDF) Toxicity review of diisononyl phthalate (DINP). 2010

    Toxicity review of diisononyl phthalate (DINP). 2010 ... Summary of Carcinogenicity ... The first study showed evidence of sensiti zation on day 37 in 3/20 animals, ...

  • addition of diisononyl phthalate category proposed rule

    Addition of Diisononyl Phthalate Category Proposed Rule

    After a review of the available data, EPA preliminarily determined that there was sufficient evidence for including this category of DINP on the EPCRA Section 313 chemical list, because the DINP category can reasonably be anticipated to cause carcinogenicity and liver, kidney, and developmental toxicity. Additional Resources

  • report on phthalates recommends permanent ban on dinp

    Report on Phthalates Recommends Permanent Ban on DINP

    The interim ban on the use of diisononyl phthalate (DINP) in children’s toys and child care articles at levels greater than 0.1% be made permanent because DINP “induces antiandrogenic effects in animals, although with lesser potency than other active phthalates, and therefore can contribute to the cumulative risk from other antiandrogenic ...

  • ortho-phthalates (1,2-benzenedicarboxylic acid esters)

    ortho-Phthalates (1,2-Benzenedicarboxylic acid esters)

    contained four phthalates (DEHP, DnBP, BzBP, and DINP), as well as the phthalate alternative di(2-ethylhexyl) adipate, illustrating the potential for multiple exposures. Dicyclohexyl phthalate (DCHP) and DINP were detected only in alternative personal care products, which the authors highlighted as possible evidence of substitution.

  • dinp information - phthalates

    DINP Information - Phthalates

    About DINP Diisononyl phthalate (DINP) is used to soften or “plasticize” polyvinyl chloride (PVC), commonly referred to as vinyl. DINP is a general purpose plasticizer used in a multitude of vinyl products that demand flexibility, durability and specific functionality. While DINP’s primary function is as a softener, it is also

  • diisononyl phthalate | c26h42o4 - pubchem

    Diisononyl phthalate | C26H42O4 - PubChem

    Diisononyl phthalate (DINP) has been widely used in polyvinyl chloride (PVC) products and is ubiquitous as a substitute; however, its toxicity due to exposure remains to be determined. This study investigated the oxidative damage induced by DINP and the induced production of the pro-inflammation cytokines interleukin-1 (IL-1) and tumour ...

  • diisononyl phthalate (dinp) - home - nicnas

    Diisononyl phthalate (DINP) - Home - NICNAS

    Diisononyl phthalate (DINP) is a member of the group of esters commonly known as phthalates 1. DINP belongs to the High Molecular Weight (HMW) group with straight carbon side chain of ≥ C7 or ring structure. There are no reports of DINP being manufactured as a raw material in Australia.

  • greenscreen™ assessment for diisononyl phthalate (dinp) (cas

    GreenScreen™ Assessment for Diisononyl phthalate (DINP) (CAS

    DINP was assigned a data gap for carcinogenicity. The carcinogenicity of phthalates is controversial. While the EU RAR considered available cancer data to be of unknown relevance to humans, DINP caused multiple types of cancers in multiple species and the mechanisms are not all fully understood. Therefore, DINP is not classifiable as

  • sds - diisononyl phthalate (dinp)

    SDS - Diisononyl Phthalate (DINP)

    Diisononyl Phthalate (DINP) Page 8 Storchem Inc. • 855 Harrington Court • Burlington, Ontario L7N 3P3 • Canada www.storchem • +1 905 639 9700 • sales@storchem Carcinogenicity IARC: 2B - Group 2B: Possibly carcinogenic to humans (Diisononyl Phthalate).

  • diisononyl phthalate (dinp) | health & environmental ... - us epa

    Diisononyl Phthalate (DINP) | Health & Environmental ... - US EPA

    The aim of this study was to investigate if levels of di-2-ethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP) metabolites in serum are associated with serum concentrations of male reproductive hormones and semen quality. A secondary aim was to investigate metabolic pathways of DEHP and DiNP on semen quality and reproductive hormones.

  • chronic toxicity and carcinogenic evaluation of diisononyl

    Chronic Toxicity and Carcinogenic Evaluation of Diisononyl

    Groups of 110 Fischer 344 rats/sex were fed diisononyl phthalate (DINP) at dietary levels of 0, 0.03, 0.3, and 0.6 wt% for periods up to 2 years. Interim sacrifices of 10 predesignated rats/sex/dose were at 6, 12, and 18 months with surviving animals sacrificed at 24 months. At study termination, survival was in excess of 60% for every group.

  • us california added diisononyl phthalate to the proposition

    US California Added Diisononyl Phthalate to the Proposition

    US California Added Diisononyl Phthalate to the Proposition 65 List In December, 2013, California’s Office of Environmental Health Hazard Assessment (OEHHA) Carcinogen Identification Committee (CIC) decided to add Diissononyl phthalate (DINP) to the Proposition 65 list as carcinogen.

  • report on phthalates recommends permanent ban on dinp

    Report on Phthalates Recommends Permanent Ban on DINP

    The interim ban on the use of diisononyl phthalate (DINP) in children’s toys and child care articles at levels greater than 0.1% be made permanent because DINP “induces antiandrogenic effects in animals, although with lesser potency than other active phthalates, and therefore can contribute to the cumulative risk from other antiandrogenic ...

  • american chemistry council files lawsuit for removal of the

    American Chemistry Council Files Lawsuit for Removal of the

    WASHINGTON -- The American Chemistry Council (ACC) Monday filed a lawsuit challenging the state of California’s listing of diisononyl phthalate (DINP) under the Safe Drinking Water and Toxic Enforcement Act of 1986, also known as Proposition 65.

  • chronic toxicity and carcinogenic evaluation of diisononyl

    Chronic Toxicity and Carcinogenic Evaluation of Diisononyl

    Studies using rat hepatocyte culture indicate that the monoester, rather than the alcohol, is the active form of Diisononyl phthalate (DINP) is an isomeric mixture of DLNP that stimulates peroxisomes (Benford et al., 1986; diesters of orf/io-phthalic acid and primary aliphatic Rhodes et al., 1984).

  • in the court of appeal of the state of california third

    IN THE COURT OF APPEAL OF THE STATE OF CALIFORNIA THIRD

    The chemical at issue here, diisononyl phthalate (“DINP”), does not pose a cancer hazard to humans. In fact, DINP is a common and useful chemical that has been used for decades to soften vinyl . 1. The Safe Drinking Water and Toxic Enforcement Act of 1986, Health & Safety Code §§25249.5-.13, is commonly referred to as Proposition 65.